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If you take line 10, get off at Maubert-Mutualité station, about a 6-minute walk from the monument. You can also take line 7, Place Monge station, about 8 minutes on foot, passing through Rue Monge and the Place du Puits de l’Ermite.
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If you're coming from the outskirts of Paris or other areas connected to the RER B line. Luxembourg station (line B) leaves you just a 5-minute walk from the Panthéon.
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If you're driving, you’ll find several public parking lots near the Panthéon. Although traffic in the center can be heavy during peak hours, you can park in nearby lots like Indigo Val de Grâce, Lagrange-Maubert, or Panthéon-Soufflot.
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You can use the 'Vélib' public bike system. The nearest station is N5032 – Panthéon – Valette, located right in front of the monument. You’ll also find additional docking points in nearby streets.